Disease of the Fatty Liver Steatosis Hepatitis: Etiology, Pathogenesis, Clinical Characteristics, Diagnosis, and Management

Niyozova Yorqinoy  Mirzaxamdamovna

doi:10.51699/cajmns.v6i4.2995

Authors

Niyozova Yorqinoy Mirzaxamdamovna Andijan State Medical Institute Assistant of the Department of Outpatient and Polyclinic Therapy

DOI:

https://doi.org/10.51699/cajmns.v6i4.2995

Keywords:

fatty liver, hepatic steatosis, non-alcoholic fatty liver disease, alcohol, hepatocytes, metabolic syndrome

Abstract

Fatty liver disease, or hepatic steatosis, has emerged as one of the most common metabolic disorders worldwide, characterized by excessive lipid accumulation in hepatocytes that disrupts liver structure and function. Its increasing prevalence has been a result of increasing incidence of obesity, diabetes and alcohol drinking, even in Uzbekistan, with recent studies reporting high levels of non-alcoholic fatty liver disease (NAFLD) among diabetic and obese populations. Although the burden is rising, the epidemiology, diagnostic criteria, and management outcome of this disease do not have enough region-specific data. This paper sought to examine the prevalence, risk factors, and clinical aspects of fatty liver disease through national hospital records, FibroScan examinations, and ultrasonography data that were obtained in 2022-2025. Quantitative and clinical data was studied to establish correlations between metabolic disorders and hepatic steatosis. Results showed that NAFLD was found among 27 percent of those who were screened with the highest incidence in Andijan and Fergana where obesity and carbohydrate diets are predominant. High ALT and AST, and imaging showed that there was a strong involvement of the hepatic. The findings highlight obesity, insulin resistance, and impoverished food as overriding contributors of fatty liver disease. The study highlights the urgent need for early screening, lifestyle modification, and multidisciplinary management to prevent disease progression to cirrhosis or hepatocellular carcinoma. These findings have important implications for national health strategies focused on metabolic disease prevention and liver health promotion in Uzbekistan.

References

G. C. Farrell and C. Z. Larter, "Nonalcoholic fatty liver disease: from steatosis to cirrhosis," Hepatology, vol. 43, no. 2 Suppl 1, pp. S99–S112, 2006.

Z. M. Younossi et al., "Global epidemiology of nonalcoholic fatty liver disease: Meta-analytic assessment of prevalence, incidence, and outcomes," Hepatology, vol. 64, no. 1, pp. 73–84, 2016.

B. Gao and R. Bataller, "Alcoholic liver disease: pathogenesis and new therapeutic targets," Gastroenterology, vol. 141, no. 5, pp. 1572–1585, 2011.

P. Angulo, "Nonalcoholic fatty liver disease," N. Engl. J. Med., vol. 346, no. 16, pp. 1221–1231, 2002.

H. Tilg and A. R. Moschen, "Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis," Hepatology, vol. 52, no. 5, pp. 1836–1846, 2010.

E. M. Brunt, "Pathology of fatty liver disease," Mod. Pathol., vol. 20, Suppl 1, pp. S40–S48, 2007.

P. Bedossa, "Pathology of non-alcoholic fatty liver disease," Liver Int., vol. 37, Suppl 1, pp. 85–89, 2017.

N. Chalasani et al., "The diagnosis and management of non-alcoholic fatty liver disease: Practice guidance from the AASLD," Hepatology, vol. 67, no. 1, pp. 328–357, 2018.

S. Milić and D. Štimac, "Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment," Dig. Dis., vol. 30, no. 2, pp. 158–162, 2012.

A. J. McCullough, "The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease," Clin. Liver Dis., vol. 8, no. 3, pp. 521–533, 2004.

T. C. Schreuder, B. J. Verwer, C. M. van Nieuwkerk, and C. J. Mulder, "Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment," World J. Gastroenterol., vol. 14, no. 16, pp. 2474–2486, 2008.

B. Li, C. Zhang, and Y. T. Zhan, "Nonalcoholic fatty liver disease cirrhosis: a review of its epidemiology, risk factors, clinical presentation, diagnosis, management, and prognosis," Can. J. Gastroenterol. Hepatol., vol. 2018, Art. no. 2784537, 2018.

P. Sharma and A. Arora, "Clinical presentation of alcoholic liver disease and non-alcoholic fatty liver disease: spectrum and diagnosis," Transl. Gastroenterol. Hepatol., vol. 5, p. 19, 2020.

N. Chalasani et al., "The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases," Hepatology, vol. 67, no. 1, pp. 328–357, 2018.

S. M. Abd El-Kader and E. M. S. El-Den Ashmawy, "Non-alcoholic fatty liver disease: The diagnosis and management," World J. Hepatol., vol. 7, no. 6, pp. 846–858, 2015.