Modern Concepts of Insulin-Like Growth Factors in Normal Conditions and Their Role in Diabetes Mellitus

Abstract

Decreased or no release of insulin from the β -cells of the pancreas plays a major role in the development of diabetes. It is also associated with the stimulation of the pituitary gland (because the anterior pituitary secretes a hormone that acts against insulin), which increases the amount of sugar in the blood and urine. The release of large amounts of glucagon from pancreatic α-cells also causes hyperglycemia. Parenteral administration of large amounts of glucose also develops diabetes .